Since their 2010 self-titled debut, The Secret Sisters have brought their spellbinding harmonies to songs that untangle the thorniest aspects of life, love and womanhood.

In the making of their new album, “Mind, Man, Medicine,” Alabama-bred siblings Laura Rogers and Lydia Slagle found their songwriting transformed by a newfound sense of self-reliance and equanimity, threading their lyrics with hard-won insight into the complexities of motherhood, commitment, compassion and self-preservation in an endlessly chaotic world.

Centered on a kaleidoscopic sound that boldly blurs the edges of country-folk, the duo’s fifth full-length ultimately confronts many of modern life’s harshest challenges, while leading the listener toward a more open-hearted state of mind.

The follow-up to “Saturn Return” — their 2020 Grammy-nominated LP co-produced by Brandi Carlile and lavishly praised by the likes of Rolling Stone — “Mind, Man, Medicine” finds The Secret Sisters co-producing alongside Ben Tanner (Alabama Shakes, St. Paul & the Broken Bones) and John Paul White (formerly of Grammy-winning duo The Civil Wars).

Tickets are $50 per person. For more information and/or to purchase tickets, visit highlandermountainhouse.com or call 828.526.2590.